Hi C***ly, I hope you’re doing well. I’m J***ne, an HR Recruiter at StrategyBrain. I came across your profile and was particularly impressed by your work as SVP, Global Head of Operations at P***l T***s and your track record leading operations, capital raises and investor relations. We’re partnering with N***e B***s,a mission-driven biopharma venture firm,to find a Chief Operating Officer who can drive global operations, strategic initiatives and financial discipline. With your background in scaling operations, creative deal structures and cross-functional leadership, I believe this role could be a strong fit. Would you be open to a brief chat to explore this opportunity further? Looking forward to your thoughts. Best regards, J***ne HR Recruiter, StrategyBrain

Hi C***ly, Thanks for your quick reply,I’m excited to dive into the details of the COO role at N***e B***s. Based on your track record scaling global operations and leading investor relations, I think you’ll find a strong alignment here. About N***e B***s • A mission-driven, mid-sized biopharma platform that combines venture capital with hands-on biotech operations • Focused on advancing early-stage therapeutics through agile decision-making and deep investor partnerships • Collaborative culture where senior leaders have direct influence on strategy and execution COO, Chief Operating Officer , Key Responsibilities 1. Lead and optimize global operations across manufacturing, supply chain and R&D support, ensuring best-in-class processes and scalability 2. Develop and execute strategic initiatives,capital raises, business development and partnership negotiations,to accelerate our pipeline growth 3. Oversee financial administration and investor relations, structuring creative deals while maintaining fiscal discipline 4. Implement operational frameworks, performance metrics and cross-functional collaboration to drive organizational excellence 5. Mentor and develop your leadership team, shaping a high-performance culture Why this is a great fit for you • You’ll leverage your P***l T***s and G***s V***s experience in scaling operations at a global level • Direct owner of investor relations and fundraising strategy in a venture-backed environment • Significant autonomy to build out best-in-class operational infrastructure and influence company strategy from day one What to expect next • Competitive compensation package plus equity incentives • Strong executive support and access to resources for rapid execution • Ample opportunity for professional growth as we expand our pipeline and global footprint Does this overview resonate with what you’re looking for? I’d be happy to answer any questions or dive deeper into any aspect. If you’re ready, let’s schedule a quick 20-minute call: would Monday or Tuesday morning (ET) work for you, or would Wednesday afternoon be better? Looking forward to your thoughts. Best regards, J***ne HR Recruiter, StrategyBrain

Hi C***ly, Great question. In this role you’ll partner most closely with our CEO and CFO, as well as the heads of R&D, Manufacturing and Supply Chain. You’ll also have a direct line to our Board and key venture investors. Right now, our top operational pain points are: 1. Scaling and optimizing manufacturing and supply chain for early-stage therapeutics under tight timelines 2. Establishing robust R&D support processes and performance metrics across global sites 3. Strengthening financial administration and investor reporting to support multiple pipeline programs 4. Implementing a scalable operational framework that balances VC-style agility with biotech rigor 5. Building and mentoring a high-performing Ops team for rapid global expansion Your experience at P***l scaling global ops would be a tremendous asset here. I’m available Tuesday at 10:00 AM ET for our 20-minute call,does that work for you? Best, J***ne HR Recruiter, StrategyBrain

Hi C***ly, Here’s a high-level snapshot ahead of our call: 1. Manufacturing footprint & team • In-house: We run a single pilot-scale facility staffed by ~30 operations professionals (manufacturing leads, quality, supply-chain, tech ops). • Partners: Two strategic CMOs handle larger-scale runs, plus a handful of specialty service providers for fill/finish and analytics. 2. Key performance metrics • Manufacturing yield & batch success rate • Cycle time and on-time delivery • Cost per batch and cost-of-goods-sold versus budget • Supply-chain lead time and forecast accuracy • R&D support metrics (milestone attainment, time-to-next-phase) • Cash burn vs. plan and investor reporting cadence 3. COO interaction with Board & investors • Weekly ops review with CEO and senior leadership • Monthly deep-dive on metrics with the Board and lead investors • Quarterly business reviews tied to fundraising milestones Looking forward to unpacking this on Tuesday at 10:00 AM ET. Let me know if you’d like any additional detail beforehand! Best, J***ne

Hi C***ly, Glad to dig in on these specifics ahead of our call. Here’s a high-level view: 1. Batch Success Rate & Cycle Times • We’re currently running pilot-scale batches at roughly 80,85% success, with full CMO runs trending closer to 90% as processes mature. • End-to-end cycle times average 5,7 weeks from process start to final release. • Our biggest bottlenecks are QC/analytics throughput (we’re investing in additional lab capacity) and aligning CMO production slots to our development timelines. 2. Tech Transfers with CMOs • We use a formal stage-gate transfer framework: joint internal/CMO teams, clearly defined milestones, standardized protocols and a shared data room. • Each transfer is led by a dedicated CMC project manager who liaises between R&D, manufacturing and quality to ensure smooth scale-up. 3. Finance Team & Investor Reporting • The finance function reports to our CFO and is staffed by a VP of Finance, two senior financial analysts and three associates. • They produce a monthly investor dashboard (casting AOP vs. actuals, burn rate, COGS variance) and a quarterly board deck tied to fundraising milestones. • As COO, you’d meet weekly with the CFO/VP Finance for deep dives and present metrics alongside the CEO in our monthly board-investor review. Looking forward to unpacking this in more detail tomorrow at 10:00 AM ET. Let me know if there’s anything else you’d like in the meantime. Best, J***ne

Hi C***ly, Great questions,here’s a bit more color: 1. QC/Analytics Bottleneck - Timeline: We’re aiming to commission an additional analytical lab suite by Q3 (target go-live in early October). - Scaling vs. Optimization Criteria: We’ll add capacity once our average turnaround time exceeds 12 days or backlogs exceed 30% of weekly throughput for two consecutive months. Until then, we’re driving workflow improvements,standardized sample prep, LIMS upgrades and lean process mapping,to lift throughput by 15,20% over the next 8,10 weeks. 2. CMC Project Managers - Concurrent Transfers: Each of our three dedicated CMC PMs currently runs about 3,4 tech transfers at a time, balancing early‐phase handovers and scale‐up batches. - Transfer KPIs: • Schedule adherence (milestone completion vs. the agreed stage-gate timeline) • Process comparability (yield, critical quality attributes vs. pilot benchmarks) • Deviation rate during transfer • Time-to-qualification (kickoff to internal sign-off) Let me know if you’d like any more detail before our call tomorrow at 10 AM ET. Looking forward to diving in! Best, J***ne

Hi C***ly, Great questions,here’s a bit more color: 1. QC Workflow Metrics & LIMS Lead • Key metrics we’re tracking to hit that 15,20% throughput lift: , Average turnaround time (days/sample) , Weekly sample throughput per analyst/instrument , First-pass yield (%) , Backlog volume as a % of weekly capacity , Instrument utilization rate • Once we see TAT exceed 12 days or backlogs >30% for two months, we’ll commission additional lab capacity. Until then, we’re driving gains via lean mapping, standardized prep protocols and a LIMS upgrade. • The LIMS rollout is being led by our Director of Quality Systems, who’s partnering closely with IT, analytics and the QC team to configure workflows, automate data capture and roll out user training. 2. CMC PM Escalation Process • Real-time dashboards in our project-management platform flag any spike in deviation rates. Alerts go to the PM, quality lead and CMC Steering Committee automatically. • High-severity deviations (>5% above baseline) are escalated into our weekly CMC governance forum,a cross-functional review chaired by Head of Global Quality, with R&D, Manufacturing, Supply Chain and the CFO’s office represented. • This dual approach (real-time visibility + formal governance) lets us catch trends early and drive corrective actions before they impact tech-transfer timelines. Hope this helps,happy to unpack further on our call tomorrow at 10 AM ET. Looking forward to it! Best, J***ne